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1. (WO2017171134) PHARMACEUTICAL COMPOSITION OF MATERIAL FOR PREVENTION AND TREATMENT OF DENTAL CARIES, COMPRISING FLUORIDE VARNISH AND ANTIBACTERIAL SUBSTANCE AS ACTIVE INGREDIENTS
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Pub. No.: WO/2017/171134 International Application No.: PCT/KR2016/005628
Publication Date: 05.10.2017 International Filing Date: 27.05.2016
IPC:
A61K 33/16 (2006.01) ,A61K 31/122 (2006.01) ,A61K 8/21 (2006.01) ,A61K 8/35 (2006.01) ,A61Q 11/00 (2006.01)
Applicants: WONKWANG UNIVERSITY CENTER FOR INDUSTRY-ACADEMY COOPERATION[KR/KR]; (Sin-dong) 460, Iksan-daero Iksan-si Jeollabuk-do 54538, KR
Inventors: BAE, Ji-Myung; KR
SON, Ju-Lee; KR
Agent: KIM, Bo-min; KR
Priority Data:
10-2016-003670228.03.2016KR
Title (EN) PHARMACEUTICAL COMPOSITION OF MATERIAL FOR PREVENTION AND TREATMENT OF DENTAL CARIES, COMPRISING FLUORIDE VARNISH AND ANTIBACTERIAL SUBSTANCE AS ACTIVE INGREDIENTS
(FR) COMPOSITION PHARMACEUTIQUE DE MATÉRIAU POUR LA PRÉVENTION ET LE TRAITEMENT DE CARIES DENTAIRES, COMPRENANT UN VERNIS DE FLUORURE ET UNE SUBSTANCE ANTIBACTÉRIENNE COMME PRINCIPES ACTIFS
(KO) 불소 바니쉬 및 항균물질을 유효성분으로 함유하는 치아 우식증 예방 및 치료용 물질의 약학적 조성물
Abstract: front page image
(EN) The present invention relates to a pharmaceutical composition for the prevention and treatment of dental caries, comprising fluoride varnish and an antibacterial substance as active ingredients. A fluoride varnish composition, of the present invention, comprising Xanthorrhizol, Bakuchiol, Bavachalcone, Isobavachromene or Bavachromene exhibits significant antibacterial activity against a Streptococcus mutans (S.mutans) strain which causes dental caries and, in particular, the composition exhibits remarkable antibacterial activity compared with the antibacterial activity of Xanthorrhizol, Bakuchiol, Bavachalcone, Isobavachromene, Bavachromene or fluoride varnish. Therefore, the fluoride varnish comprising Xanthorrhizol, Bakuchiol, Bavachalcone, Isobavachromene or Bavachromene can be usefully used for the prevention and treatment of dental caries.
(FR) La présente invention concerne une composition pharmaceutique pour la prévention et le traitement de caries dentaires, comprenant un vernis de fluorure et une substance antibactérienne comme principes actifs. Une composition de vernis à base de fluorure, selon la présente invention, comprenant du xanthorrhizol, du bakuchiol, du bavachalcone, de l'isobapachromolène ou du bavachromène présente une activité antibactérienne importante contre une souche de Streptococcus mutans (S.mutans) qui provoque des caries dentaires et, en particulier, la composition présente une activité antibactérienne remarquable par rapport à l'activité antibactérienne de xanthorrhizol, de bakuchiol, de bavachalcone, d'isobapachromène, de bavachromène ou de vernis de fluorure. Par conséquent, le vernis à base de fluorure comprenant du xanthorrhizol, du bakuchiol, du bavachalcone, de l'isobavapachromène ou du bavachromène peut être utilisé de manière utile pour la prévention et le traitement de caries dentaires.
(KO) 본 발명은 불소 바니쉬(fluoride varnish) 및 항균물질을 유효성분으로 함유하는 치아 우식증 예방 및 치료용 약학적 조성물에 관한 것으로, 본 발명의 잔토리졸(Xanthorrhizol), 바쿠치올(Bakuchiol), 바바칼콘(Bavachalcone), 이소바바크로민(Isobavachromene) 또는 바바크로민(Bavachromene)을 포함하는 불소 바니쉬 조성물은 치아 우식증을 일으키는 스트렙토코커스 뮤탄스(Streptococcus mutans; S.mutans) 균주에 대하여 유의적인 항균활성을 나타내고, 특히 잔토리졸, 바쿠치올, 바바칼콘, 이소바바크로민, 바바크로민 또는 불소 바니쉬의 항균활성과 비교하여 상기 조성물은 현저한 항균활성을 나타내므로, 상기 잔토리졸, 바쿠치올, 바바칼콘, 이소바바크로민 또는 바바크로민을 포함하는 불소 바니쉬는 치아 우식증 예방 및 치료에 유용하게 사용될 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)