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1. (WO2017170764) TABLET CONTAINING SPHERICAL ADSORPTIVE CARBON FOR ORAL ADMINISTRATION AND PRODUCTION METHOD THEREOF
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Pub. No.: WO/2017/170764 International Application No.: PCT/JP2017/013050
Publication Date: 05.10.2017 International Filing Date: 29.03.2017
IPC:
A61K 33/44 (2006.01) ,A61J 3/06 (2006.01) ,A61K 47/10 (2017.01) ,A61K 47/32 (2006.01) ,A61K 47/34 (2017.01) ,A61K 47/36 (2006.01) ,A61K 47/38 (2006.01) ,A61K 47/42 (2017.01) ,A61K 47/46 (2006.01) ,A61K 9/20 (2006.01) ,A61P 1/16 (2006.01) ,A61P 13/12 (2006.01) ,A61P 39/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33
Medicinal preparations containing inorganic active ingredients
44
Elemental carbon, e.g. charcoal, carbon black
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
J
CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
3
Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
06
into the form of pills, lozenges or dragees
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
10
Alcohols; Phenols; Salts thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
32
Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
34
Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
36
Polysaccharides; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
36
Polysaccharides; Derivatives thereof
38
Cellulose; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
42
Proteins; Polypeptides; Degradation products thereof; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
46
Ingredients of undetermined constitution or reaction products thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
16
for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13
Drugs for disorders of the urinary system
12
of the kidneys
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
39
General protective or antinoxious agents
02
Antidotes
Applicants: KUREHA CORPORATION[JP/JP]; 3-3-2, Nihonbashi-Hamacho, Chuo-ku, Tokyo 1038552, JP
Inventors: MACHI, Yoshiki; JP
KOYA, Yohei; JP
ONO, Saichi; JP
KONISHI, Mayu; JP
SHIMADA, Hironao; JP
Agent: SHOBAYASHI, Masayuki; JP
HAYASHI, Kazuyoshi; JP
NIIYAMA, Yuichi; JP
Priority Data:
2016-07458001.04.2016JP
Title (EN) TABLET CONTAINING SPHERICAL ADSORPTIVE CARBON FOR ORAL ADMINISTRATION AND PRODUCTION METHOD THEREOF
(FR) COMPRIMÉ CONTENANT DES PARTICULES SPHÉRIQUES ADSORBANTES DE CHARBON POUR UNE ADMINISTRATION PAR VOIE ORALE, ET PROCÉDÉ DE PRODUCTION DE CE DERNIER
(JA) 経口投与用球状吸着炭を含む錠剤及びその製造方法
Abstract:
(EN) The purpose of the present invention is to provide a tablet, and a production method thereof, which has a high absorption rate of spherical adsorptive carbon for oral administration, and a high uniformity of the spherical adsorptive carbon for oral administration and a binder additive. This purpose is met with: a tablet characterized in that the ratio between the maximum value and the minimum value of the additive volume fraction per 1 mm³ in five prescribed rectangular columns is less than or equal to 100; a tablet characterized in that the relative standard deviation of the volume fraction of three prescribed divided cubic bodies is less than or equal to 5%; or a tablet characterized in that the ratio between the maximum value and the minimum value of the additive volume fraction per 1 mm³ in five prescribed rectangular columns is less than or equal to 100 and in that the relative standard deviation of the volume fraction of three prescribed divided cubic bodies is less than or equal to 5%.
(FR) L'objectif de la présente invention est de fournir un comprimé, et un procédé de production de ce dernier, qui présente un fort taux d'absorption des particules sphériques adsorbantes de charbon pour administration par voie orale, et une grande uniformité des particules sphériques adsorbantes de charbon pour administration par voie orale, et un additif à rôle de liant. Cet objectif est atteint par : un comprimé caractérisé en ce que le rapport entre la valeur maximale et la valeur minimale de la fraction volumique d'additif pour 1 mm³ dans cinq colonnes rectangulaires prescrites est inférieur ou égal à 100 ; un comprimé caractérisé en ce que l'écart type relatif de la fraction volumique de trois corps cubiques divisés prescrits est inférieur ou égal à 5 % ; ou un comprimé caractérisé en ce que le rapport entre la valeur maximale et la valeur minimale de la fraction volumique d'additif par 1 mm³ dans cinq colonnes rectangulaires prescrites est inférieur ou égal à 100 et en ce que l'écart type relatif de la fraction volumique de trois corps cubiques divisés prescrits est inférieur ou égal à 5 %.
(JA) 本発明の目的は、経口投与用球状吸着炭の収率が高く、経口投与用球状吸着炭及び結着用添加剤の均一性が高い錠剤及びその製造方法を提供することである。前記課題は、所定の5つの角柱における1mm当たりの添加剤体積率の最大値及び最小値の比が100以下であることを特徴とする、錠剤;所定の3つの分割体の立方体の体積率の相対標準偏差が5%以下であることを特徴とする、錠剤;又は所定の5つの角柱における1mm当たりの添加剤体積率の最大値及び最小値の比が100以下であり、所定の3つの分割体の立方体の体積率の相対標準偏差が5%以下であることを特徴とする、錠剤によって解決することができる。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)