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1. (WO2017170571) EYE DISEASE BIOMARKER
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/170571    International Application No.:    PCT/JP2017/012689
Publication Date: 05.10.2017 International Filing Date: 28.03.2017
IPC:
C12N 15/09 (2006.01), C12M 1/34 (2006.01), C12Q 1/32 (2006.01), C12Q 1/68 (2006.01)
Applicants: OSAKA UNIVERSITY [JP/JP]; 1-1, Yamadaoka, Suita-shi, Osaka 5650871 (JP)
Inventors: NISHIDA, Kohji; (JP).
KUMANOGOH, Atsushi; (JP).
HASHIDA, Noriyasu; (JP)
Agent: TANAKA, Junya; (JP).
MIUTANI, Keiya; (JP)
Priority Data:
2016-064685 28.03.2016 JP
Title (EN) EYE DISEASE BIOMARKER
(FR) BIOMARQUEUR DE MALADIE OCULAIRE
(JA) 眼科疾患のバイオマーカー
Abstract: front page image
(EN)A principal purpose of the present invention is to provide a biomarker which makes it possible to conveniently and accurately assess a corneal or conjunctival disease, and can use lacrimal fluid as the sample therefor. In addition, another principal purpose of the present invention is to provide a biomarker which makes it possible to conveniently and accurately assess central serous chorioretinopathy. The present invention also provides a diagnosis kit containing a reagent capable of detecting said biomarker, and a diagnosis method that uses said biomarker. It is possible to use mitochondrial DNA included in lacrimal fluid as the biomarker for corneal or conjunctival disease.
(FR)Un objectif principal de la présente invention est de fournir un biomarqueur qui permet d'évaluer de manière pratique et précise une maladie cornéenne ou conjonctivale, et peut utiliser un fluide lacrymal comme échantillon pour celui-ci. De plus, un autre objectif principal de la présente invention est de fournir un biomarqueur qui permet d'évaluer de manière pratique et précise une choriorétinopathie séreuse centrale. La présente invention concerne également un kit de diagnostic contenant un réactif capable de détecter ledit biomarqueur, et un procédé de diagnostic qui utilise ledit biomarqueur. Il est possible d'utiliser l'ADN mitochondrial inclus dans le fluide lacrymal en tant que biomarqueur pour une maladie cornéenne ou conjonctivale.
(JA)本発明は、涙液をサンプルとして適用でき、角膜又は結膜疾患を簡便かつ正確に評価することができるバイオマーカーを提供することを主な目的とする。また、本発明は、中心性漿液性脈絡網膜症を簡便かつ正確に評価することができるバイオマーカーを提供することを主な目的とする。また、本発明は、当該バイオマーカーを演出することが可能な試薬を含む診断キット、及び、当該バイオマーカーを利用した診断方法を提供する。涙液中に含まれるミトコンドリアDNAが角膜又は結膜疾患のバイオマーカーになり得る。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)