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1. (WO2017168313) AN IMPROVED PROCESS FOR THE PREPARATION OF DROXIDOPA AND ITS INTERMEDIATE

Pub. No.:    WO/2017/168313    International Application No.:    PCT/IB2017/051757
Publication Date: Fri Oct 06 01:59:59 CEST 2017 International Filing Date: Wed Mar 29 01:59:59 CEST 2017
IPC: C07C 227/32
C07C 229/36
C07B 53/00
C07F 15/04
C07D 317/54
C07C 227/40
Applicants: PIRAMAL ENTERPRISES LIMITED
Inventors: GHARPURE, Milind
JAGTAP, Ashutosh
RAUT, Changdev
KANSAGARA, Nainesh
KRISHNAPILLAI, Jaisankar
MANOHARAN, Nirmal Kumar
PATIL, Navnath
Title: AN IMPROVED PROCESS FOR THE PREPARATION OF DROXIDOPA AND ITS INTERMEDIATE
Abstract:
The present invention provides an improved process for preparation of L-threo-(2S,3R)-3-(3.4- dihydroxyphenyl)serine (I) (Droxidopa) and its salts; comprising (a) reaction of the aldehyde compound (III) (as described herein) with Metal complex (II) (as described herein), and (b) hydrolysis of the compound (IV) obtained from step (a) in presence of acid. The present invention also relates to a novel intermediates metal chiral complex (IV) for the preparation of Droxidopa.