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1. (WO2017168313) AN IMPROVED PROCESS FOR THE PREPARATION OF DROXIDOPA AND ITS INTERMEDIATE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/168313    International Application No.:    PCT/IB2017/051757
Publication Date: 05.10.2017 International Filing Date: 28.03.2017
IPC:
C07C 227/32 (2006.01), C07C 229/36 (2006.01), C07B 53/00 (2006.01), C07F 15/04 (2006.01), C07D 317/54 (2006.01), C07C 227/40 (2006.01)
Applicants: PIRAMAL ENTERPRISES LIMITED [IN/IN]; Piramal Tower Ganpatrao Kadam Marg Lower Parel Mumbai 400013 (IN)
Inventors: GHARPURE, Milind; (IN).
JAGTAP, Ashutosh; (IN).
RAUT, Changdev; (IN).
KANSAGARA, Nainesh; (IN).
KRISHNAPILLAI, Jaisankar; (IN).
MANOHARAN, Nirmal Kumar; (IN).
PATIL, Navnath; (IN)
Priority Data:
201621010969 30.03.2016 IN
Title (EN) AN IMPROVED PROCESS FOR THE PREPARATION OF DROXIDOPA AND ITS INTERMEDIATE
(FR) PROCÉDÉ AMÉLIORÉ DE PRÉPARATION DE DROXIDOPA ET SON INTERMÉDIAIRE
Abstract: front page image
(EN)The present invention provides an improved process for preparation of L-threo-(2S,3R)-3-(3.4- dihydroxyphenyl)serine (I) (Droxidopa) and its salts; comprising (a) reaction of the aldehyde compound (III) (as described herein) with Metal complex (II) (as described herein), and (b) hydrolysis of the compound (IV) obtained from step (a) in presence of acid. The present invention also relates to a novel intermediates metal chiral complex (IV) for the preparation of Droxidopa.
(FR)La présente invention concerne un procédé amélioré de préparation de L-thréo-(2S,3R)-3-(3,4-dihydroxyphényl)sérine (I) (Droxidopa) et ses sels; comprenant (a) la réaction du composé aldéhyde (III) (tel que décrit dans la description) avec un complexe métallique (II) (tel que décrit dans la description), et (b) l'hydrolyse du composé (IV) obtenu à partir de l'étape (a) en présence d'un acide. La présente invention décrit également un nouveau complexe chiral métallique intermédiaire (IV) destiné à la préparation de Droxidopa.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)