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1. (WO2017168161) MODIFIED ENZYME

Pub. No.:    WO/2017/168161    International Application No.:    PCT/GB2017/050901
Publication Date: Fri Oct 06 01:59:59 CEST 2017 International Filing Date: Fri Mar 31 01:59:59 CEST 2017
IPC: C12N 9/10
C12N 15/52
C12P 7/02
C12N 9/02
Applicants: ZUVASYNTHA LIMITED
Inventors: GRADLEY, Michelle
BARTOSIAK-JENTYS, Jeremy
GÖRNER, Christian
KENDALL, John
Title: MODIFIED ENZYME
Abstract:
The present invention provides a modified 2-deoxyribose phosphate aldolase (DERA) enzyme variant comprising one or more mutations that improve the aldolase catalytic performance for synthesis of 3-hydroxybutanal or crotonaldehyde, relative to the parent DERA enzyme from which the variant originates and which does not comprise such a modification.