Search International and National Patent Collections

1. (WO2017167988) ADENOVIRAL COAT PROTEIN DERIVED DELIVERY VEHICLES

Pub. No.:    WO/2017/167988    International Application No.:    PCT/EP2017/057747
Publication Date: Fri Oct 06 01:59:59 CEST 2017 International Filing Date: Sat Apr 01 01:59:59 CEST 2017
IPC: C12N 15/86
C07K 14/005
C12N 7/00
A61K 39/12
Applicants: THE EUROPEAN MOLECULAR BIOLOGY LABORATORY
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
Inventors: BERGER, Imre
GARZONI, Frédéric
FENDER, Pascal
Title: ADENOVIRAL COAT PROTEIN DERIVED DELIVERY VEHICLES
Abstract:
The present invention relates to new adenoviral coat protein based delivery vehicles. They are based on a modified penton base protomers that assemble into VLPs. Exposed areas of the penton base proteins can be modified to allow the VLP to specifically bind to any target and/or to comprise any desired peptide epitope. Additional cargo, e.g. drugs, proteins, or nucleic acids, can reversibly or irreversibly attached to the VLP via engineered fibre protein fragments. The present invention relates to such engineered penton base protomers, engineered proteins comprising an adenovirus fibre protein N-terminal fragment specifically binding to an adenovirus fibre protein binding cleft of a penton base protomer, VLPs comprising the engineered penton base protomers and optionally engineered proteins comprising an adenovirus fibre protein N-terminal fragment specifically binding to an adenovirus fibre protein binding cleft of a penton base protomer, nucleic encoding the engineered proteins, the VLPs as well as methods of producing the proteins and VLPs.