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1. (WO2017167953) SUBSTITUTED INDOLINE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/167953 International Application No.: PCT/EP2017/057663
Publication Date: 05.10.2017 International Filing Date: 31.03.2017
IPC:
C07D 209/26 (2006.01) ,A61K 31/404 (2006.01) ,A61P 31/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
condensed with one carbocyclic ring
04
Indoles; Hydrogenated indoles
10
with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
18
Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
26
with an acyl radical attached to the ring nitrogen atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403
condensed with carbocyclic rings, e.g. carbazole
404
Indoles, e.g. pindolol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
Applicants: JANSSEN PHARMACEUTICALS, INC.[US/US]; 1125 Trenton-Harbourton Road Titusville, NJ New Jersey 08560, US
KATHOLIEKE UNIVERSITEIT LEUVEN[BE/BE]; Waaistraat 6, bus 5105 3000 Leuven, BE
Inventors: BARDIOT, Dorothée Alice Marie-Eve; BE
BONFANTI, Jean-François; FR
KESTELEYN, Bart Rudolf Romanie; BE
MARCHAND, Arnaud Didier M; BE
RABOISSON, Pierre Jean-Marie Bernard; BE
Agent: VERBERCKMOES, Filip; BE
Priority Data:
16163281.531.03.2016EP
Title (EN) SUBSTITUTED INDOLINE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS
(FR) DÉRIVÉS D'INDOLINE SUBSTITUÉE UTILISÉS EN TANT QU'INHIBITEURS DE LA RÉPLICATION DU VIRUS DE LA DENGUE
Abstract:
(EN) The present invention concerns substituted indoline compounds, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
(FR) La présente invention concerne des dérivés d'indoline substituée, des procédés pour prévenir ou traiter des infections par le virus de la dengue à l'aide desdits composés. L'invention concerne également lesdits composés pour une utilisation en tant que médicament, plus préférablement pour une utilisation en tant que médicament pour traiter ou prévenir des infections par le virus de la dengue. La présente invention concerne en outre des compositions pharmaceutiques ou des préparations de combinaison des composés, les compositions ou les préparations destinées à être utilisées en tant que médicament, plus préférablement pour la prévention ou le traitement d'infections par le virus de la dengue. L'invention concerne enfin des procédés de préparation des composés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)