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1. (WO2017167182) SELECTIVE C-KIT KINASE INHIBITOR
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/167182 International Application No.: PCT/CN2017/078437
Publication Date: 05.10.2017 International Filing Date: 28.03.2017
IPC:
C07D 211/44 (2006.01) ,C07D 401/04 (2006.01) ,C07D 413/04 (2006.01) ,C07D 413/14 (2006.01) ,C07D 401/14 (2006.01) ,C07D 409/14 (2006.01) ,A61K 31/45 (2006.01) ,A61K 31/4545 (2006.01) ,A61K 31/454 (2006.01) ,A61P 35/00 (2006.01) ,A61P 35/02 (2006.01)
Applicants: PRECEDO PHARMACEUTICALS CO., LTD[CN/CN]; Room 1405-1 Wang Jiang Xi Road, No.860, Innovation Building B Hi-Tech Industry Development Zone (HTZ) Hefei, Anhui 230031, CN
HEFEI GRACEVO BIO-MEDICINE CO., LTD[CN/CN]; Level 9, Building 7, Independent Innovation Industry Base Zhenxing Road, New Industrial Park of Shushan District Hefei, Anhui 230000, CN
Inventors: LIU, Qingsong; CN
LIU, Jing; CN
WANG, Qiang; CN
WANG, Beilei; CN
LIU, Feiyang; CN
QI, Shuang; CN
QI, Ziping; CN
ZOU, Fengming; CN
CHEN, Cheng; CN
WANG, Wenchao; CN
HU, Chen; CN
LIU, Xiaochuan; CN
WANG, Wei; CN
WANG, Aoli; CN
WANG, Li; CN
HU, Zhenquan; CN
REN, Tao; CN
Agent: SHANGCHENG & PARTNERS; 1801 18th Floor, Ever Bright World Center No. 28 West Ping An Li Avenue, Xicheng District Beijing 100034, CN
Priority Data:
201610210424.X01.04.2016CN
Title (EN) SELECTIVE C-KIT KINASE INHIBITOR
(FR) INHIBITEUR SÉLECTIF DE LA KINASE C-KIT
(ZH) 一种选择性的C-KIT激酶抑制剂
Abstract: front page image
(EN) The present invention provides a compound represented by formula (I), or a pharmaceutically acceptable salt, a solvate, an ester, an acid, a metabolite or a prodrug thereof. The compound itself in the present invention or in combination with at least one therapeutic agent can be used for preventing or treating diseases, disorders or symptoms caused by the adjustment of the activity of tyrosine kinase C-KIT, or affected by the activity of the tyrosine kinase C-KIT or involving in the activity of the tyrosine kinase C-KIT, especially cancers or other cell proliferation diseases.
(FR) La présente invention concerne un composé représenté par la formule (I), ou un sel pharmaceutiquement acceptable, un solvate, un ester, un acide, un métabolite ou un promédicament de celui-ci. Le composé lui-même dans la présente invention ou en combinaison avec au moins un agent thérapeutique peut être utilisé pour prévenir ou traiter des maladies, des troubles ou des symptômes provoqués par l'ajustement de l'activité de la tyrosine kinase C-KIT, ou affecté par l'activité de la tyrosine kinase C-KIT ou impliquant l'activité de la tyrosine kinase C-KIT, en particulier des cancers ou d'autres maladies de prolifération cellulaire.
(ZH) 本发明提供一种式(I)的化合物或其药学可接受的盐、溶剂化物、酯、酸、代谢物、或前药。本发明的化合物单独与至少一种另外的治疗剂联合给药可用于预防或治疗由酪氨酸激酶C-KIT活性调节的或者受其影响的或者其中涉及酪氨酸激酶C-KIT活性的疾病、障碍或病症,尤其是癌症和其它细胞增殖性疾病。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)