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1. (WO2017167180) VORTIOXETINE PAMOIC ACID SALT AND CRYSTAL FORM THEREOF

Pub. No.:    WO/2017/167180    International Application No.:    PCT/CN2017/078427
Publication Date: Fri Oct 06 01:59:59 CEST 2017 International Filing Date: Wed Mar 29 01:59:59 CEST 2017
IPC: C07D 295/096
C07C 65/11
C07C 51/41
A61K 31/495
A61P 25/24
A61P 25/30
A61P 25/32
A61P 25/28
A61P 25/04
A61P 25/00
A61P 29/00
Applicants: SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO., LTD
上海华汇拓医药科技有限公司
Inventors: LI, Yunfei
李云飞
XIA, Xiaoer
夏小二
XU, Xin
许昕
ZHANG, Zhen
张瑱
LIU, Lei
刘磊
ZHANG, Xiaojuan
张小娟
ZHANG, Liming
张立明
LI, Dongsheng
李东升
WANG, Yijin
王艺瑾
GE, Jian
葛建
Title: VORTIOXETINE PAMOIC ACID SALT AND CRYSTAL FORM THEREOF
Abstract:
The present invention provides a vortioxetine pamoic acid salt, which includes a crystal form, a solvate or an amorphous substance of the vortioxetine pamoic acid salt. The present invention provides a preparation method and use of the vortioxetine pamoic acid salt and the crystal form thereof. The vortioxetine pamoic acid salt prepared in the present invention prolongs the residence time of the vortioxetine in vivo, achieving a slow release of the vortioxetine in vivo, and is suitable for preparing a long-acting dosage form.