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1. (WO2017161179) COMPOSITIONS FOR THE REMINERALIZATION OF DENTIN
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/161179 International Application No.: PCT/US2017/022799
Publication Date: 21.09.2017 International Filing Date: 16.03.2017
IPC:
A61K 6/027 (2006.01) ,A61K 6/033 (2006.01) ,A61K 6/02 (2006.01) ,A61K 6/08 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
6
Preparations for dentistry
02
Use of preparations for artificial teeth, for filling or for capping teeth
027
Use of non-metallic elements or compounds thereof, e.g. carbon
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
6
Preparations for dentistry
02
Use of preparations for artificial teeth, for filling or for capping teeth
027
Use of non-metallic elements or compounds thereof, e.g. carbon
033
Phosphorus compounds, e.g. apatite
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
6
Preparations for dentistry
02
Use of preparations for artificial teeth, for filling or for capping teeth
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
6
Preparations for dentistry
02
Use of preparations for artificial teeth, for filling or for capping teeth
08
Use of natural or synthetic resins
Applicants:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street Oakland, California 94607, US
THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. [US/US]; 288 Grinter Hall Gainesville, Florida 32611, US
Inventors:
MARSHALL, Grayson; US
MARSHALL, Sally; US
NURROHMAN, Hamid; US
SAEKI, Kuniko; US
HABELITZ, Stefan; US
GOWER, Laurie; US
Agent:
BERMAN, Matthew; US
Priority Data:
62/309,78517.03.2016US
Title (EN) COMPOSITIONS FOR THE REMINERALIZATION OF DENTIN
(FR) COMPOSITIONS POUR LA REMINÉRALISATION DE LA DENTINE
Abstract:
(EN) Provided herein are novel compositions for the restoration of demineralized tissues, such as dentin which has been demineralized by tooth decay. The remineralization agent comprises a bioactive ceramic component and a polyanionic macromolecular component, which may be admixed and applied to the target tissue and which will subsequently set to produce a remineralizing solid. The remineralizing solid will produce nanodroplets of mineral precursor solution, which such nanodroplets can infiltrate demineralized collagen matrices and which will form hydroxyapatite crystals therein by polymer-induced liquid precursor processes. The scope of the invention encompasses novel compositions and methods of treating demineralized tissues.
(FR) L'invention concerne de nouvelles compositions destinées à la restauration de tissus déminéralisés, tels que la dentine ayant été déminéralisée par une carie dentaire. L'agent de reminéralisation comprend un constituant céramique bioactif et un constituant macromoléculaire polyanionique, qui peuvent être mélangés et appliqués sur le tissu cible et qui seront ensuite durcis pour former une matière solide reminéralisante. La matière solide reminéralisante produira des nano-gouttelettes de solution de précurseur minérale, lesdites nano-gouttelettes pouvant infiltrer des matrices de collagène déminéralisées et formeront des cristaux d'hydroxyapatite dans lesdites matrices par des processus précurseurs liquides induits par polymère. L'invention concerne de nouvelles compositions et des procédés de traitement de tissus déminéralisés.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20190083363