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1. WO2017158379 - CHLORHEXIDINE CRYSTAL FORMS AND USES THEREOF IN MEDICINE

Publication Number WO/2017/158379
Publication Date 21.09.2017
International Application No. PCT/GB2017/050752
International Filing Date 17.03.2017
IPC
C07C 279/26 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
279Derivatives of guanidine, i.e. compounds containing the group the singly-bound nitrogen atoms not being part of nitro or nitroso groups
20containing any of the groups X being a hetero atom, Y being any atom, e.g. acylguanidines
24Y being a hetero atom
26X and Y being nitrogen atoms, i.e. biguanides
A61K 31/155 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
155Amidines , e.g. guanidine , isourea , isothiourea
A61P 31/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
CPC
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
C07B 2200/13
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200Indexing scheme relating to specific properties of organic compounds
13Crystalline forms, e.g. polymorphs
C07C 279/265
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
279Derivatives of guanidine, i.e. compounds containing the group , the singly-bound nitrogen atoms not being part of nitro or nitroso groups
20containing any of the groups , X being a hetero atom, Y being any atom, e.g. acylguanidines
24Y being a hetero atom
26X and Y being nitrogen atoms, i.e. biguanides
265containing two or more biguanide groups
Applicants
  • QUEEN MARY UNIVERSITY OF LONDON [GB]/[GB]
Inventors
  • CATTEL, Michael
  • SUKHORUKOV, Gleb
  • SHAHID, Saroash
  • LUO, Dong
Agents
  • BASSIL, Nicholas
Priority Data
1604639.318.03.2016GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CHLORHEXIDINE CRYSTAL FORMS AND USES THEREOF IN MEDICINE
(FR) FORMES CRISTALLINES DE CHLORHEXIDINE ET LEURS UTILISATIONS EN MÉDECINE
Abstract
(EN)
The present invention provides a crystalline salt of chlorhexidine chloride having a spherical morphology under Scanning Electron Microscopy (SEM) comprising a chloride anion and a cation selected from the group consisting of calcium, sodium, potassium, magnesium, zinc, strontium or iron, processes for the preparation of the salt, compositions, pharmaceutical compositions and uses thereof in medicine. Also provided are crystalline forms of the salt and fibres comprising the same.
(FR)
La présente invention décrit un sel cristallin de chlorure de chlorhexidine présentant une morphologie sphérique sous microscopie électronique à balayage (MEB) comprenant un anion chlorure et un cation sélectionnés dans le groupe constitué du calcium, du sodium, du potassium, du magnésium, du zinc, du strontium ou du fer, des procédés de préparation du sel, des compositions, ou des compositions pharmaceutiques et leurs utilisations en médecine. Sont également décrites des formes cristallines du sel et des fibres le comprenant.
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