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1. WO2017158067 - METHOD AND SYSTEM FOR OPTIMISATION OF DBS PROGRAMMING

Publication Number WO/2017/158067
Publication Date 21.09.2017
International Application No. PCT/EP2017/056184
International Filing Date 15.03.2017
IPC
A61B 5/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
A61B 5/048 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
04Measuring bioelectric signals of the body or parts thereof
0476Electroencephalography
048Detecting the frequency distribution of signals
A61N 1/36 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
1Electrotherapy; Circuits therefor
18Applying electric currents by contact electrodes
32alternating or intermittent currents
36for stimulation, e.g. heart pace-makers
CPC
A61B 5/0031
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
0002Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
0031Implanted circuitry
A61B 5/2415
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
2415Measuring direct current [DC] or slowly varying biopotentials
A61B 5/374
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
316Modalities, i.e. specific diagnostic methods
369Electroencephalography [EEG]
372Analysis of electroencephalograms
374Detecting the frequency distribution of signals, e.g. detecting delta, theta, alpha, beta or gamma waves
A61B 5/4064
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
40Detecting, measuring or recording for evaluating the nervous system
4058for evaluating the central nervous system
4064Evaluating the brain
A61B 5/4836
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
48Other medical applications
4836Diagnosis combined with treatment in closed-loop systems or methods
A61B 5/7225
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
72Signal processing specially adapted for physiological signals or for diagnostic purposes
7225Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation
Applicants
  • UNIVERSITÄT BERN [CH]/[CH]
Inventors
  • TINKHAUSER, Gerd
  • BROWN, Peter
  • POGOSYAN, Alek
  • SCHÜPBACH, Michael
  • POLLO, Claudio
  • DEBOVE, Ines
Agents
  • VENI GMBH
Priority Data
EP16160544.915.03.2016EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHOD AND SYSTEM FOR OPTIMISATION OF DBS PROGRAMMING
(FR) PROCÉDÉ ET SYSTÈME D’OPTIMISATION DE LA PROGRAMMATION DE DBS
Abstract
(EN) A method and system are described for, based upon a plurality of previously-acquired directional LFP signals measured in a plurality of different directions at a directional sensor lead located in a predetermined region of a patient's brain, determining optimised patient-specific programming parameters for programming a directional stimulation lead with parameters for stimulating the said region. The method comprises a first step of determining, over at least one predetermined frequency range, a power-frequency variation curve of each of the directional LFP signals, a second step of identifying frequency peaks in the power- frequency variation curves, a third step of detecting one of the identified frequency peaks at which a maximum difference in signal power between the directional LFP signals occurs, and a fourth step of calculating a plurality of directional stimulation weighting factors on the basis of the relative signal powers of the directional LFP signals at the detected frequency peak.
(FR) La présente invention décrit un procédé et un système destinés, sur la base d’une pluralité de signaux LFP directionnels précédemment acquis mesurés dans une pluralité de sens différents au niveau d’une borne de capteur directionnel située dans une région prédéterminée d’un cerveau d’un patient, la détermination des paramètres de programmation optimisés spécifiques au patient pour la programmation d’une borne de stimulation directionnelle avec des paramètres de stimulation de ladite région. Le procédé comprend une première étape de détermination, sur au moins une plage de fréquences prédéterminée, d’une courbe de variation de puissance-fréquence de chacun des signaux LFP directionnels, une seconde étape d’identification de pics de fréquence dans les courbes de variation puissance-fréquence, une troisième étape de détection de l’un des pics de fréquence identifiés auquel une différence maximale dans la puissance du signal entre les signaux LFP directionnels se produit, et une quatrième étape de calcul d’une pluralité de facteurs de pondération de stimulation directionnelle sur la base des puissances de signaux relatives des signaux LFP directionnels au pic de fréquence détecté.
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