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|1. (WO2017157418) COMBINATION OF MKNK1-INHIBITORS|
|Applicants:||BAYER PHARMA AKTIENGESELLSCHAFT
SANTAG, Susann Corinna
WENGNER, Antje Margret
|Title:||COMBINATION OF MKNK1-INHIBITORS|
The present invention relates to combinations of at least two components, component A and component B, component A being a MKNK1-inhibitor of general formula (I), or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, in particular a pharmaceutically acceptable salt, or a mixture of same, and component B being an anti-hyperproliferative, cytotoxic and/or cytostatic agent selected from a taxane, such as docetaxel or paclitaxel, or combinations thereof, and pemetrexed. Another aspect of the present invention relates to the use of such combinations as described supra for the preparation of a medicament for the treatment or prophylaxis of a disease, particurlarly for the treatment of cancer and/or metastases thereof.