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1. (WO2017157418) COMBINATION OF MKNK1-INHIBITORS

Pub. No.:    WO/2017/157418    International Application No.:    PCT/EP2016/055499
Publication Date: Fri Sep 22 01:59:59 CEST 2017 International Filing Date: Wed Mar 16 00:59:59 CET 2016
IPC: A61K 31/00
A61K 31/5025
A61K 31/337
A61K 35/00
Applicants: BAYER PHARMA AKTIENGESELLSCHAFT
Inventors: SIEGEL, Franziska
PETERSEN, Kirstin
SANTAG, Susann Corinna
WENGNER, Antje Margret
EIS, Knut
MICHELS, Martin
Title: COMBINATION OF MKNK1-INHIBITORS
Abstract:
The present invention relates to combinations of at least two components, component A and component B, component A being a MKNK1-inhibitor of general formula (I), or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, in particular a pharmaceutically acceptable salt, or a mixture of same, and component B being an anti-hyperproliferative, cytotoxic and/or cytostatic agent selected from a taxane, such as docetaxel or paclitaxel, or combinations thereof, and pemetrexed. Another aspect of the present invention relates to the use of such combinations as described supra for the preparation of a medicament for the treatment or prophylaxis of a disease, particurlarly for the treatment of cancer and/or metastases thereof.