Search International and National Patent Collections

1. (WO2017157325) FUSION PROTEIN COMPRISING NERVE GROWTH FACTOR AND PREPARATION METHOD AND USE THEREOF

Pub. No.:    WO/2017/157325    International Application No.:    PCT/CN2017/077025
Publication Date: Fri Sep 22 01:59:59 CEST 2017 International Filing Date: Sat Mar 18 00:59:59 CET 2017
IPC: C07K 19/00
C12N 15/62
C12N 15/85
A61K 38/18
A61P 25/28
A61P 3/04
Applicants: STAIDSON(BEIJING) BIOPHARMACEUTICALS CO.,LTD.
舒泰神(北京)生物制药股份有限公司
Inventors: ZHANG, Qingshuang
张晴爽
MA, Lei
马磊
LIU, Ming
刘明
Title: FUSION PROTEIN COMPRISING NERVE GROWTH FACTOR AND PREPARATION METHOD AND USE THEREOF
Abstract:
The present invention relates to the field of biopharmaceuticals and provides a fusion protein comprising a nerve growth factor (NGF) and a preparation method and use thereof. The fusion protein has a general formula represented by A-B or A-L-B, wherein A is a nerve growth factor, L is a linker peptide, and B is an Fc moiety of IgG, or an analogue of the Fc moiety of IgG, or a fragment of the Fc moiety of IgG. The fusion protein of the present invention has the following advantages over a wild-type NGF: higher biological activity, a half-life more than 17 times longer, greatly reduced administration frequency, and significantly increased efficacy.