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|1. (WO2017157325) FUSION PROTEIN COMPRISING NERVE GROWTH FACTOR AND PREPARATION METHOD AND USE THEREOF|
|Applicants:||STAIDSON(BEIJING) BIOPHARMACEUTICALS CO.,LTD.
|Title:||FUSION PROTEIN COMPRISING NERVE GROWTH FACTOR AND PREPARATION METHOD AND USE THEREOF|
The present invention relates to the field of biopharmaceuticals and provides a fusion protein comprising a nerve growth factor (NGF) and a preparation method and use thereof. The fusion protein has a general formula represented by A-B or A-L-B, wherein A is a nerve growth factor, L is a linker peptide, and B is an Fc moiety of IgG, or an analogue of the Fc moiety of IgG, or a fragment of the Fc moiety of IgG. The fusion protein of the present invention has the following advantages over a wild-type NGF: higher biological activity, a half-life more than 17 times longer, greatly reduced administration frequency, and significantly increased efficacy.