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1. (WO2017157323) LIPOPOLYSACCHARIDE BINDING PROTEIN POLYPEPTIDE AND PHARMACEUTICAL USE THEREOF

Pub. No.:    WO/2017/157323    International Application No.:    PCT/CN2017/076969
Publication Date: Fri Sep 22 01:59:59 CEST 2017 International Filing Date: Fri Mar 17 00:59:59 CET 2017
IPC: C07K 7/08
A61K 38/10
A61P 31/04
Applicants: SOOCHOW UNIVERSITY
苏州大学
Inventors: WU, Yi
武艺
XIE, Zhanli
谢展利
YANG, Aizhen
阳艾珍
Title: LIPOPOLYSACCHARIDE BINDING PROTEIN POLYPEPTIDE AND PHARMACEUTICAL USE THEREOF
Abstract:
Provided are a lipopolysaccharide (LPS) binding protein polypeptide and the pharmaceutical use thereof, wherein the amino acid sequence of the lipopolysaccharide binding protein polypeptide is DHGHKHKHGHGHGKH, and the lipopolysaccharide binding protein polypeptide is derived from a high molecular weight kininogen (HK) protein in human plasma itself. The lipopolysaccharide binding protein polypeptide is injected into a mouse through intraperitoneal injection, and can reduce the mortality of endotoxemia caused by LPS in mice and inhibit the production of inflammatory factors.