Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2017157305) MULTISPECIFIC FAB FUSION PROTEINS AND USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/157305 International Application No.: PCT/CN2017/076816
Publication Date: 21.09.2017 International Filing Date: 15.03.2017
IPC:
C07K 16/30 (2006.01) ,C07K 16/46 (2006.01) ,A61K 39/395 (2006.01) ,A61P 35/00 (2006.01)
[IPC code unknown for C07K 16/30][IPC code unknown for C07K 16/46][IPC code unknown for A61K 39/395][IPC code unknown for A61P 35]
Applicants:
GENERON (SHANGHAI) CORPORATION LTD. [CN/CN]; Suite 307, 1011 Ha Lei Road China (Shanghai) Pilot Free Trade Zone Shanghai 201203, CN
Inventors:
CUI, Yumin; CN
HUANG, Zhihua; CN
CHEN, Hanyang; CN
ZHANG, Xinfeng; CN
QI, Bo; CN
YAN, Xiaoqiang; CN
Agent:
WU, FENG & ZHANG; Sinosteel Plaza, 21st Floor A/D 8 Haidian st., Haidian Beijing 100080, CN
Priority Data:
201610147227.815.03.2016CN
Title (EN) MULTISPECIFIC FAB FUSION PROTEINS AND USE THEREOF
(FR) PROTÉINES DE FUSION À FAB MULTISPÉCIFIQUES ET LEUR UTILISATION
Abstract:
(EN) The present invention provides multispecific Fab fusion proteins (MSFP) that specifically bind to CD3 and EpCAM. The present invention further provides uses of the MSFPs for the preparation of pharmaceutical compositions, methods of treating cancer, and kits comprising the MSFPs. Also provided are anti-EpCAM antibodies or antigen-binding fragments thereof.
(FR) La présente invention concerne des protéines de fusion à Fab multispécifiques (MSFP) qui se lient spécifiquement au CD3 et à EpCAM. La présente invention concerne en outre des utilisations des MSFP pour la préparation de compositions pharmaceutiques, des procédés de traitement du cancer, et des kits comprenant les MSFP. L'invention concerne également des anticorps anti-EpCAM ou des fragments de liaison à l'antigène de ceux-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)