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1. (WO2017157260) PHENYLPROPANOID AND PREPARATION METHOD AND APPLICATION THEREOF

Pub. No.:    WO/2017/157260    International Application No.:    PCT/CN2017/076455
Publication Date: Fri Sep 22 01:59:59 CEST 2017 International Filing Date: Tue Mar 14 00:59:59 CET 2017
IPC: C07H 15/203
A61K 31/7034
A61K 36/738
A61K 36/758
A61K 36/486
A61K 36/29
A61K 36/19
A61P 29/00
A61P 19/02
A61P 15/00
Applicants: QIANJIN PHARMACEUTICAL CO., LTD.
株洲千金药业股份有限公司
Inventors: ZHANG, Peng
张鹏
PENG, Kaifeng
彭开锋
GONG, Yun
龚云
LI, Fujun
李伏君
LIU, Nifu
刘逆夫
XIA, Bohou
夏伯候
LIN, Limei
林丽美
Title: PHENYLPROPANOID AND PREPARATION METHOD AND APPLICATION THEREOF
Abstract:
Provided are a phenylpropanoid and a preparation method and application thereof. The phenylpropanoid has a structure represented by formula (I), and a pharmaceutically acceptable salt thereof has a structure represented by formula (II) or formula (III). The phenylpropanoid and the pharmaceutically acceptable salt thereof are capable of suppressing the amount of the inflammatory cytokine NO and the expression of the inflammatory cytokine TNF-α and inhibiting the hydroxy free radical -OH, and hence have anti-inflammatory and anti-oxidant activities. Thus, the phenylpropanoid and the pharmaceutical acceptable salt thereof have a good prospect of application in the preparation of a medicament for treating diseases associated with the above factors, including inflammatory diseases such as cervicitis, endometritis, pelvic inflammatory disease, mastitis, esophagitis and arthritis.