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1. (WO2017157205) MULTI-FUNCTIONAL FUSION POLYPEPTIDE, PREPARATION METHOD THEREOF, AND APPLICATION OF SAME

Pub. No.:    WO/2017/157205    International Application No.:    PCT/CN2017/075861
Publication Date: Fri Sep 22 01:59:59 CEST 2017 International Filing Date: Wed Mar 08 00:59:59 CET 2017
IPC: C07K 19/00
C07K 14/00
C07K 1/02
C07K 1/04
C07K 1/06
A61K 38/16
A61P 35/00
A61P 11/00
Applicants: NANJING ANJI BIOLOGICAL TECHNOLOGY CO.,LTD
南京安吉生物科技有限公司
Inventors: XU, Hanmei
徐寒梅
Title: MULTI-FUNCTIONAL FUSION POLYPEPTIDE, PREPARATION METHOD THEREOF, AND APPLICATION OF SAME
Abstract:
Provided are a multi-functional fusion polypeptide, a preparation method thereof, and an application of same. The polypeptide incorporates functional domains of Pro-(D-Pyr)-(D-Cys)-Bip-Arg-Gly-Glu, Ile-Val-Arg-Arg-Ala-Asp-Arg-Ala-Ala-Val-Pro, Arg-Gly-Asp, and Gly-Gly-Gly-Gly. In a pulmonary fibrosis cell model, the polypeptide reduced the concentration of a hydroxyproline in a cell of a model group and suppressed the progression of pulmonary fibrosis. In an MTT assay, the polypeptide suppressed human tumor cell proliferation.