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|1. (WO2017157188) MULTI-ARMED POLYETHYLENE GLYCOL AND ACTIVE DERIVATIVE THEREOF|
|Applicants:||JENKEM TECHNOLOGY CO., LTD. (BEIJING)
|Title:||MULTI-ARMED POLYETHYLENE GLYCOL AND ACTIVE DERIVATIVE THEREOF|
Provided are a polyol glyceryl ether, and a multi-armed polyethylene glycol and the multi-armed polyethylene glycol active derivative prepared using same. The multi-armed polyethylene glycol is formed by polymerizing ethylene oxide with the polyol glyceryl ether as an initiator, and has the structure of general formula II, wherein B is a polyol group, n is an integer between 3 and 22, PEG is the same or different -(OCH2CH2)m-, and the average value of m is an integer between 3 and 250. The multi-armed polyethylene glycol has a relatively low poly-dispersity and a relatively high determined molecular weight. Also provided is a conjugate of the multi-armed polyethylene glycol active derivative and pharmaceutical molecules, a pharmaceutical composition comprising the conjugate, and a gel formed by the multi-armed polyethylene glycol active derivative. The gel can be used to prepare a sustained-release drug for prolonging the time of the drug action.