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1. (WO2017157188) MULTI-ARMED POLYETHYLENE GLYCOL AND ACTIVE DERIVATIVE THEREOF

Pub. No.:    WO/2017/157188    International Application No.:    PCT/CN2017/075599
Publication Date: Fri Sep 22 01:59:59 CEST 2017 International Filing Date: Sat Mar 04 00:59:59 CET 2017
IPC: C08G 65/28
C07C 41/03
C07C 43/13
A61K 47/60
A61K 9/06
A61K 31/4745
Applicants: JENKEM TECHNOLOGY CO., LTD. (BEIJING)
北京键凯科技股份有限公司
Inventors: WEI, Zhen
魏真
LIN, Meina
林美娜
ZHU, Zhengang
朱振刚
ZHAO, Xuan
赵宣
Title: MULTI-ARMED POLYETHYLENE GLYCOL AND ACTIVE DERIVATIVE THEREOF
Abstract:
Provided are a polyol glyceryl ether, and a multi-armed polyethylene glycol and the multi-armed polyethylene glycol active derivative prepared using same. The multi-armed polyethylene glycol is formed by polymerizing ethylene oxide with the polyol glyceryl ether as an initiator, and has the structure of general formula II, wherein B is a polyol group, n is an integer between 3 and 22, PEG is the same or different -(OCH2CH2)m-, and the average value of m is an integer between 3 and 250. The multi-armed polyethylene glycol has a relatively low poly-dispersity and a relatively high determined molecular weight. Also provided is a conjugate of the multi-armed polyethylene glycol active derivative and pharmaceutical molecules, a pharmaceutical composition comprising the conjugate, and a gel formed by the multi-armed polyethylene glycol active derivative. The gel can be used to prepare a sustained-release drug for prolonging the time of the drug action.