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1. (WO2017157137) NEW TYPE ACYCLIC NUCLEOSIDE ANALOGUE AND PHARMACEUTICAL COMPOSITION THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/157137 International Application No.: PCT/CN2017/074191
Publication Date: 21.09.2017 International Filing Date: 21.02.2017
IPC:
C07F 9/6561 (2006.01) ,C07B 59/00 (2006.01) ,A61K 31/675 (2006.01) ,A61P 31/18 (2006.01) ,A61P 31/20 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
547
Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
6561
containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
B
GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
59
Introduction of isotopes of elements into organic compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
66
Phosphorus compounds
675
having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
14
for RNA viruses
18
for HIV
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
20
for DNA viruses
Applicants:
深圳市塔吉瑞生物医药有限公司 SHENZHEN TARGETRX, INC. [CN/CN]; 中国广东省深圳 南山区科苑路15号科兴科学园A1栋301 Room 301,Building A1 Kexing Science Park, No.15 of Keyuan Road, Nanshan District Shenzhen, Guangdong 5180057, CN
Inventors:
王义汉 WANG, Yihan; CN
赵九洋 ZHAO, Jiuyang; CN
Priority Data:
201610152273.717.03.2016CN
Title (EN) NEW TYPE ACYCLIC NUCLEOSIDE ANALOGUE AND PHARMACEUTICAL COMPOSITION THEREOF
(FR) NOUVEAU TYPE D'ANALOGUE DE NUCLÉOSIDE ACYCLIQUE ET COMPOSITION PHARMACEUTIQUE CORRESPONDANTE
(ZH) 一种新型的无环核苷类似物及其药物组合物
Abstract:
(EN) Provided in the present invention is a new type acyclic nucleoside analogue and a pharmaceutical composition thereof, wherein the new type nucleoside analogue is the compound as shown by formula (I), or a crystal form, a pharmaceutically acceptable salt, a prodrug, a stereisomer, a hydrate or a solvate thereof. The compound of the present invention can inhibit the activity of a nucleoside reverse transcriptase, and at the same time, has a better pharmacodynamics/pharmacokinetics performance. The compound has a good applicability and high safety, and can be used to prepare drugs for treating diseases related to viral infections.
(FR) La présente invention concerne un nouveau type d'analogue de nucléoside acyclique et une composition pharmaceutique correspondante, le nouveau type d'analogue de nucléoside étant le composé tel que représenté par la formule (I), ou une forme cristalline, un sel pharmaceutiquement acceptable, un promédicament, un stéréo-isomère, un hydrate ou un solvate correspondants. Le composé de la présente invention peut inhiber l'activité d'une transcriptase inverse nucléosidique et, en même temps, présente une meilleure performance pharmacodynamique/pharmacocinétique. Le composé présente une bonne applicabilité et une sécurité élevée et peut être utilisé pour préparer des médicaments pour traiter des maladies liées à des infections virales.
(ZH) 本发明提供了一种新型的无环核苷类似物及其药物组合物,所述新型的无环核苷类似物如为式(I)所示的化合物,或其晶型、药学上可接受的盐、前药、立体异构体、水合物或溶剂化合物。本发明的化合物可抑制核苷类逆转录酶活性,同时具有更好药效学/药代动力学性能,化合物的适用性好、安全性高,可用于制备治疗病毒感染相关疾病的药物。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)