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1. (WO2017157131) USE OF CHLOROGENIC ACID IN PREPARING PHARMACEUTICALS FOR TREATMENT OF LAG-3-MEDIATED DISEASE

Pub. No.:    WO/2017/157131    International Application No.:    PCT/CN2017/074065
Publication Date: Fri Sep 22 01:59:59 CEST 2017 International Filing Date: Tue Feb 21 00:59:59 CET 2017
IPC: A61K 31/216
A61K 9/20
A61P 35/00
A61P 31/12
A61P 31/14
Applicants: SICHUAN JIUZHANG BIO-TECHNOLOGY CO., LTD.
四川九章生物科技有限公司
Inventors: ZHANG, Jie
张洁
CHEN, Xiaoguang
陈晓光
XUE, Nina
薛妮娜
ZHANG, Mengtian
张梦甜
Title: USE OF CHLOROGENIC ACID IN PREPARING PHARMACEUTICALS FOR TREATMENT OF LAG-3-MEDIATED DISEASE
Abstract:
Provided are a use of chlorogenic acid in preparing pharmaceuticals for the inhibition of LAG-3 and a use of chlorogenic acid in preparing pharmaceuticals for the treatment of LAG-3-mediated diseases. The inhibition of LAG-3 by chlorogenic acid is useful in cancer therapy, anti-viral therapy, and sepsis treatment. The oral bioavailability of chlorogenic acid is enhanced by preparing chlorogenic acid as a gastric floating tablet.