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1. (WO2017156959) MICROMOLECULAR LUNG-TARGETING DRUG
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2017/156959 International Application No.: PCT/CN2016/092829
Publication Date: 21.09.2017 International Filing Date: 02.08.2016
IPC:
C07D 493/04 (2006.01) ,A61K 31/365 (2006.01) ,A61P 11/00 (2006.01) ,A61P 35/00 (2006.01) ,A61P 37/06 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
493
Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
365
Lactones
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
06
Immunosuppressants, e.g. drugs for graft rejection
Applicants:
重庆药友制药有限责任公司 YAOPHARMA CO., LTD. [CN/CN]; 中国重庆市 渝北区人和镇星光大道100号 100 Xingguang Avenue, Renhe Town, Yubei Distrct Chongqing 401121, CN
Inventors:
张志荣 ZHANG, Zhirong; CN
周美玲 ZHOU, Meiling; CN
张彦 ZHANG, Yan; CN
Agent:
北京集佳知识产权代理有限公司 UNITALEN ATTORNEYS AT LAW; 中国北京市 朝阳区建国门外大街22号赛特广场7层 7th Floor, Scitech Place No. 22, Jian Guo Men Wai Ave. Chao Yang District Beijing 100004, CN
Priority Data:
201610151988.017.03.2016CN
Title (EN) MICROMOLECULAR LUNG-TARGETING DRUG
(FR) MÉDICAMENT MICROMOLÉCULAIRE CIBLANT LES POUMONS
(ZH) 一种小分子肺靶向药物
Abstract:
(EN) A compound represented by formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable formulation prepared using the compound and the salt. The compound represented by formula (I) or the pharmaceutically acceptable salt exhibits significantly higher buildup and concentration in the lungs compared to other tissues, a longer dwell time in the lungs, and/or elevated pharmaceutical efficacy.
(FR) L'invention concerne un composé représenté par la formule (I) ou un sel pharmaceutiquement acceptable de celui-ci, et une formulation pharmaceutiquement acceptable préparée à l'aide du composé et du sel. Le composé représenté par la formule (I) ou le sel pharmaceutiquement acceptable présente une accumulation et une concentration considérablement plus élevées dans les poumons par rapport à d'autres tissus, une durée de séjour plus longue dans les poumons et/ou une efficacité pharmaceutique élevée.
(ZH) 一种通式I的化合物或其药学上可接受的盐,含有其化合物及其盐制得的药学上可接受的制剂。通式(I)的化合物或其药学上可接受的盐在体内具有显著高于其它组织的肺部聚集浓度、肺部停留时间和/或提高的药物作用效果。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)