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1. (WO2017156764) ISOLATED NUCLEIC ACID APPLICATION THEREOF

Pub. No.:    WO/2017/156764    International Application No.:    PCT/CN2016/076708
Publication Date: Fri Sep 22 01:59:59 CEST 2017 International Filing Date: Sat Mar 19 00:59:59 CET 2016
IPC: C12Q 1/04
G06F 19/22
A61P 19/08
Applicants: SHANGHAI REALBIO TECHNOLOGY CO.,LTD
上海锐翌生物科技有限公司
Inventors: ZHONG, Wendi
仲文迪
LIU, Wanhui
刘婉辉
ZHENG, Zhijun
郑智俊
Title: ISOLATED NUCLEIC ACID APPLICATION THEREOF
Abstract:
An isolated nucleic acid, comprising at least one of a first, a second, and a third nucleic acid sequence cluster, the nucleic acid sequences in the first, the second, and the third nucleic acid sequence cluster respectively corresponding on a one-to-one basis to the sequences shown by SEQ ID NO: 1-110, SEQ ID NO: 111-299, and SEQ ID NO: 300-453, the sequence similarity between the sequences in the first, the second, and the third nucleic acid sequence cluster and the sequences corresponding thereto being no less than 90%. A method and an apparatus for determining the state of an individual by using said isolated nucleic acid. Compared to a healthy group, the present isolated nucleic acid is significantly enriched in a group of ankylosing spondylitis patients, and can be used as a marker to distinguish between a healthy group and a group of ankylosing spondylitis patients.