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1. (WO2017156616) NANOVESICLES COMPRISING PORPHYRIN-LIPID CONJUGATES EXHIBITING ORDERED ASSEMBLY AND BATHOCHROMIC SHIFTS
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Pub. No.: WO/2017/156616 International Application No.: PCT/CA2017/000052
Publication Date: 21.09.2017 International Filing Date: 10.03.2017
IPC:
A61K 47/69 (2017.01) ,A61K 41/00 (2006.01) ,A61K 49/00 (2006.01) ,A61K 9/127 (2006.01) ,A61K 9/51 (2006.01) ,A61P 35/00 (2006.01) ,C07K 14/775 (2006.01) ,C07K 17/02 (2006.01)
[IPC code unknown for A61K 47/69]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41
Medicinal preparations obtained by treating materials with wave energy or particle radiation
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
51
Nanocapsules
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
775
Apolipopeptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
17
Carrier-bound or immobilised peptides; Preparation thereof
02
Peptides being immobilised on, or in, an organic carrier
Applicants:
UNIVERSITY HEALTH NETWORK [CA/CA]; 190 Elizabeth Street, R. Fraser Elliott Building - Room 1S-417 Toronto, Ontario M5G 2C4, CA
Inventors:
ZHENG, Gang; CA
NG, Kenneth; CA
CHEN, Juan; CA
TAKEDA, Misa; JP
HARMATYS, Kara; CA
Agent:
CHIU, Jung-Kay; Norton Rose Fulbright Canada LLP/S.E.N.C.R.L, s.r.l. 1 Place Ville Marie, Suite 2500 Montreal, Quebec H3B 1R1, CA
Priority Data:
62/310,10818.03.2016US
Title (EN) NANOVESICLES COMPRISING PORPHYRIN-LIPID CONJUGATES EXHIBITING ORDERED ASSEMBLY AND BATHOCHROMIC SHIFTS
(FR) NANOVÉSICULES COMPRENANT DES CONJUGUÉS PORPHYRINE-LIPIDE PRÉSENTANT UN ASSEMBLAGE ORDONNÉ ET DES DÉCALAGES BATHOCHROMES
Abstract:
(EN) The application relates to liposomal nanovesicles comprising porphyrin-lipid conjugates within the liposomal lipid bilayer. Said porphyrin-lipid conjugate comprise porphyrins that are modified with a -CH(R1)-O-R2 group and that chelate a metal ion. Such modifications of the porphyrin allow for ordered assembly in the lipid bilayer of the nanovesicles while resulting in a bathochromic shift in the wavelength of light absorbed by the porphyrin chromophore. These nanovesicles can be used for photothermal therapy, photodynamic therapy, photoacoustic imaging and fluorescence imaging. The application also teaches methods for preparing the porphyrin-lipid conjugates and the nanovesicles.
(FR) L'invention concerne des nanovésicules liposomales comprenant des conjugués porphyrine-lipide à l'intérieur de la bicouche lipidique liposomale. Ledit conjugué porphyrine-lipide comprend des porphyrines qui sont modifiées par un groupe -CH(R1)-O-R2 et qui chélatent un ion métallique. De telles modifications de la porphyrine permettent un assemblage ordonné dans la bicouche lipidique des nanovésicules, tout en produisant un décalage bathochrome dans la longueur d'onde de la lumière absorbée par le chromophore à base de porphyrine. Ces nanovésicules peuvent être utilisées pour de la thérapie photo-thermique, de la thérapie photo-dynamique, de l'imagerie photo-acoustique et de l'imagerie par fluorescence. L'invention concerne également des procédés de préparation des conjugués porphyrine-lipide et des nanovésicules.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)