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1. (WO2017156531) ULTRA-THIN, HIGH STRENGTH, DRUG-LOADED SUTURES AND COATINGS THEREOF

Pub. No.:    WO/2017/156531    International Application No.:    PCT/US2017/022093
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Tue Mar 14 00:59:59 CET 2017
IPC: A61L 17/10
A61L 17/12
D01H 7/02
A61L 17/00
D01D 5/00
D01F 1/10
Applicants: THE JOHNS HOPKINS UNIVERSITY
Inventors: PARIKH, Kunal, S.
HANES, Justin
ENSIGN, Laura
Title: ULTRA-THIN, HIGH STRENGTH, DRUG-LOADED SUTURES AND COATINGS THEREOF
Abstract:
Small-diameter suture materials and suture coating materials made from the twisting or braiding of biocompatible polymeric fibers have been developed, which support drug delivery and maintain a high tensile strength. The fibers entrap (e.g., encapsulate) one or more therapeutic, prophylactic or diagnostic agents and provide prolonged release over a period of at least a week, preferably a month. While monofilament fibers lose tensile strength with the inclusion of active agents, twisting the drug-loaded, multifilament fibers allows for an increase in the tensile strength for the overall composites, while still retaining a small diameter. The methods of making these materials and using them for ocular surgery and vasculature repair have also been developed.