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1. (WO2017156527) AURORA KINASE AND JANUS KINASE INHIBITORS FOR PREVENTION OF GRAFT VERSUS HOST DISEASE

Pub. No.:    WO/2017/156527    International Application No.:    PCT/US2017/022074
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Tue Mar 14 00:59:59 CET 2017
IPC: A61K 31/505
A61K 31/506
Applicants: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
Inventors: BETTS, Brian
SEBTI, Said
LAWRENCE, Harshani
LAWRENCE, Nicholas
ANASETTI, Claudio
PIDALA, Joseph
Title: AURORA KINASE AND JANUS KINASE INHIBITORS FOR PREVENTION OF GRAFT VERSUS HOST DISEASE
Abstract:
Disclosed herein are compounds and methods for reducing the risk of developing, preventing, or treating graft versus host disease (GVHD) in a subject. The compounds can concurrently block Aurora kinase A and JAK2 signal transduction which synergistically suppresses alloreactive human T-cells in vitro, prevents xenogeneic graft- versus-host disease without impairing anti-tumor responses, and promotes the development and suppressive potency of CD39+ inducible Treg. In certain aspects, disclosed are compounds of Formula I-V.