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1. (WO2017156521) PROCESS AND APPARATUS FOR MAKING ALIGNED OR TWISTED ELECTROSPUN FIBERS AND DEVICES
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Pub. No.: WO/2017/156521 International Application No.: PCT/US2017/022036
Publication Date: 14.09.2017 International Filing Date: 13.03.2017
IPC:
D01D 5/00 (2006.01) ,D01F 1/10 (2006.01) ,D01H 7/02 (2006.01) ,A61L 17/00 (2006.01)
D TEXTILES; PAPER
01
NATURAL OR ARTIFICIAL THREADS OR FIBRES; SPINNING
D
MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES, OR RIBBONS
5
Formation of filaments, threads, or the like
D TEXTILES; PAPER
01
NATURAL OR ARTIFICIAL THREADS OR FIBRES; SPINNING
F
CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES, OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
1
General methods for the manufacture of artificial filaments or the like
02
Addition of substances to the spinning solution or to the melt
10
Other agents for modifying properties
D TEXTILES; PAPER
01
NATURAL OR ARTIFICIAL THREADS OR FIBRES; SPINNING
H
SPINNING OR TWISTING
7
Spinning or twisting arrangements
02
for imparting permanent twist
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
17
Materials for surgical sutures or for ligaturing blood vessels
Applicants:
THE JOHNS HOPKINS UNIVERSITY [US/US]; 3400 N. Charles Street Baltimore, MD 21218, US
Inventors:
PARIKH, Kunal, S.; US
PATEL, Himat; US
HANES, Justin; US
Agent:
PABST, Patrea L.; US
MONHEIT, Rivka, D.; US
PABST, Patrea, L.; US
RAYMOND, Adam, S.; US
HODGES, Robert, A.; US
Priority Data:
62/307,09611.03.2016US
62/307,23011.03.2016US
Title (EN) PROCESS AND APPARATUS FOR MAKING ALIGNED OR TWISTED ELECTROSPUN FIBERS AND DEVICES
(FR) PROCÉDÉ ET APPAREIL DE FABRICATION DE FIBRES ÉLECTROFILÉES ALIGNÉES OU TORSADÉES ET DISPOSITIFS
Abstract:
(EN) A system for forming twisted or aligned electrospun fibers has been developed. The collector for the electrospun fibers is capable of rotation. In some instances, fibers are formed between two collectors, at least one of which rotates to twist the fibers into a multifilament bundle with increased strength. In a second embodiment, a cylindrical collector rotates, and charged polymer jet uniformly coats the surface of the collector. When a drum collector rotates at a high speed, electrospun fibers align and form an array. Optionally, different active agents can be included in the electrospinning solutions to form fiber constructs with different strengths and controlled release profiles, providing a reproducible method to generate complexed structures based on electrospun fibers and controlled drug delivery profiles.
(FR) Selon la présente invention, un système pour former des fibres électrofilées torsadées ou alignées a été développé. Le collecteur pour les fibres électrofilées est capable de rotation. Dans certains cas, des fibres sont formées entre deux collecteurs, dont au moins un tourne pour torsader les fibres en un faisceau de multifilaments ayant une résistance augmentée. Dans un deuxième mode de réalisation, un collecteur cylindrique tourne, et un jet de polymère chargé recouvre uniformément la surface du collecteur. Lorsqu'un collecteur cylindrique tourne à une vitesse élevée, les fibres électrofilées s'alignent et forment un réseau. Facultativement, différents agents actifs peuvent être inclus dans les solutions d'électrofilage pour former des constructions de fibres ayant différentes résistances et différents profils de libération contrôlée, de façon à obtenir un procédé reproductible pour générer des structures complexées à base de fibres électrofilées et de profils d'administration contrôlée de médicament.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)