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1. (WO2017156514) METHODS AND AGENTS FOR MODULATING CELLULAR METABOLISM AND TREATING CANCER

Pub. No.:    WO/2017/156514    International Application No.:    PCT/US2017/021993
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Mon Mar 13 00:59:59 CET 2017
IPC: A61K 31/7088
A61K 48/00
A61P 35/04
C12N 15/11
Applicants: MEMORIAL SLOAN KETTERING CANCER CENTER
Inventors: WENDEL, Hans-Guido
SINGH, Kamini
ZHONG, Yi
RATSCH, Gunnar
Title: METHODS AND AGENTS FOR MODULATING CELLULAR METABOLISM AND TREATING CANCER
Abstract:
Methods are provided for modulating cellular metabolism by exposing cells to an agent that reduces translation of MYC dependent mRNA transcripts. Such methods and agents are useful for treatment of cancer, and altering cellular metabolism.