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1. (WO2017156491) TLX AND MIR-219 AS POTENTIAL THERAPEUTIC TARGETS FOR NEURODEVELOPMENTAL DISORDERS
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Pub. No.: WO/2017/156491 International Application No.: PCT/US2017/021962
Publication Date: 14.09.2017 International Filing Date: 10.03.2017
IPC:
C12N 5/0797 (2010.01) ,C12N 15/113 (2010.01) ,C07K 14/705 (2006.01)
[IPC code unknown for C12N 5/0797][IPC code unknown for C12N 15/113][IPC code unknown for C07K 14/705]
Applicants:
CITY OF HOPE [US/US]; 1500 East Duarte Road Duarte, California 91010-3000, US
Inventors:
SHI, Yanhong; US
Agent:
DUEPPEN, Lara; US
Priority Data:
62/306,63110.03.2016US
62/307,36711.03.2016US
Title (EN) TLX AND MIR-219 AS POTENTIAL THERAPEUTIC TARGETS FOR NEURODEVELOPMENTAL DISORDERS
(FR) TLX ET MIR-219 UTILISÉS COMME CIBLES THÉRAPEUTIQUES POTENTIELLES POUR DES TROUBLES NEURODÉVELOPPEMENTAUX
Abstract:
(EN) Disclosed herein are methods of treating neurodevelopmental disorders such as schizophrenia (SCZ), bipolar disorder or depression. The methods entail inhibiting expression of miR-219 or overexpressing TLX thereby promoting proliferation of neural stem cells (NSCs) in the subjects.
(FR) La présente invention concerne des méthodes de traitement de troubles neurodéveloppementaux tels que la schizophrénie (SCZ), un trouble bipolaire ou la dépression. Les méthodes impliquent l'inhibition de l'expression de miR-219 ou la surexpression de TLX, favorisant ainsi la prolifération de cellules souches neurales (NSC) chez les sujets.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)