Search International and National Patent Collections
|1. (WO2017156488) ACTIVIN TYPE 2 RECEPTOR BINDING PROTEINS AND USES THEREOF|
|Applicants:||ACCELERON PHARMA INC.
|Title:||ACTIVIN TYPE 2 RECEPTOR BINDING PROTEINS AND USES THEREOF|
This disclosure provides ActRII-binding proteins such as anti-ActRIIA and anti-ActRIIB antibodies, and compositions and methods for making the ActRII-binding proteins. In certain aspects the ActRII-binding proteins inhibit, or antagonize ActRII activity. In addition, the disclosure provides compositions and methods for diagnosing and treating dieseases and conditions associated muscle wasting; a fibrotic condition; an inflammatory, cardiovascular, pulmonary, musculoskeletal, neurologic, ocular, skeletal, autoimmune, or metabolic disease or condition; wound healing; and cancer, and other ActRII-mediated diseases and conditions.