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1. (WO2017156488) ACTIVIN TYPE 2 RECEPTOR BINDING PROTEINS AND USES THEREOF

Pub. No.:    WO/2017/156488    International Application No.:    PCT/US2017/021958
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Sat Mar 11 00:59:59 CET 2017
IPC: C07K 14/705
C07K 16/22
C07K 14/47
C07K 16/28
C07K 14/475
A61K 39/395
A61K 31/7088
A61K 38/18
G01N 33/53
Applicants: ACCELERON PHARMA INC.
ADIMAB, LLC
Inventors: KUMAR, Ravindra
BELK, Jonathan
GRINBERG, Asya
SAKO, Dianne
CASTONGUAY, Roselyne
Title: ACTIVIN TYPE 2 RECEPTOR BINDING PROTEINS AND USES THEREOF
Abstract:
This disclosure provides ActRII-binding proteins such as anti-ActRIIA and anti-ActRIIB antibodies, and compositions and methods for making the ActRII-binding proteins. In certain aspects the ActRII-binding proteins inhibit, or antagonize ActRII activity. In addition, the disclosure provides compositions and methods for diagnosing and treating dieseases and conditions associated muscle wasting; a fibrotic condition; an inflammatory, cardiovascular, pulmonary, musculoskeletal, neurologic, ocular, skeletal, autoimmune, or metabolic disease or condition; wound healing; and cancer, and other ActRII-mediated diseases and conditions.