Search International and National Patent Collections

1. (WO2017156480) CROSSLINKERS FOR MASS SPECTROMETRIC lDENTIFICATION AND QUANTITATION OF INTERACTING PEPTIDES

Pub. No.:    WO/2017/156480    International Application No.:    PCT/US2017/021946
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Sat Mar 11 00:59:59 CET 2017
IPC: G01N 33/53
G01N 33/60
G01N 33/68
Applicants: INSTITUTE FOR SYSTEMS BIOLOGY
Inventors: LUO, Jie
RANISH, Jeff
Title: CROSSLINKERS FOR MASS SPECTROMETRIC lDENTIFICATION AND QUANTITATION OF INTERACTING PEPTIDES
Abstract:
Crosslinking molecules that permit efficient identification of specifically associated proteins and the sites of crosslinking in biological or other samples include two cleavable bonds that are cleavable under the same conditions as peptide bonds in mass spectrometric determinations. Sets of the invention crosslinkers may be provided with isobaric labels containing reporter ions of differing molecular weights to permit relative quantitation of crosslinked protein pairs.