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1. (WO2017156441) HYBRID MEMBRANE-COATED NANOPARTICLE COMPOSITES AND METHODS OF MAKING AND USING THE SAME

Pub. No.:    WO/2017/156441    International Application No.:    PCT/US2017/021880
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Sat Mar 11 00:59:59 CET 2017
IPC: B82Y 5/00
A61K 47/02
A61K 47/12
A61K 47/69
G01N 33/483
Applicants: PORTLAND STATE UNIVERSITY
Inventors: MACKIEWICZ, Marilyn
Title: HYBRID MEMBRANE-COATED NANOPARTICLE COMPOSITES AND METHODS OF MAKING AND USING THE SAME
Abstract:
Disclosed herein are embodiments of nanoparticle composites that comprise covalently coupled stabilizing agent molecules that improve stability of the nanoparticle composites and allow for tight packing of lipids and/or membranes. The nanoparticle composites can further comprise inhibition inhibitors and/or lipid components that interact to form a hybrid lipid bilayer membrane around the nanoparticle core. The nanoparticle composites can be coupled to drugs, targeting moieties, and imaging moieties. The nanoparticle composites can be used for in vivo drug deliver, disease diagnosis/treatment, and imaging.