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1. (WO2017156436) ASSAYS AND METHODS FOR DETECTING MYCOBACTERIAL INFECTIONS

Pub. No.:    WO/2017/156436    International Application No.:    PCT/US2017/021873
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Sat Mar 11 00:59:59 CET 2017
IPC: G01N 33/558
C12Q 1/68
G01N 21/00
G01N 33/483
G01N 33/569
Applicants: S&R PHARMACEUTICALS, LLC
Inventors: HSU, Tsungda
Title: ASSAYS AND METHODS FOR DETECTING MYCOBACTERIAL INFECTIONS
Abstract:
Provided herein is an assay for detecting a rough-type mycobacterium and a smooth-type mycobacterium in a sample, wherein the mycobacterium is Mycobacterium tuberculosis or Mycobacterium bovis. The assay comprises a first molecule that selectively binds to the rough- type mycobacterium or binds to a molecule preferentially secreted by the rough-type mycobacterium and a second molecule that selectively binds to the smooth-type mycobacterium or binds to a molecule preferentially secreted by the smooth-type mycobacterium. The first molecule and the second molecule are independently detectable. Also provided herein are corresponding methods for detecting a rough-type mycobacterium and a smooth-type mycobacterium in a sample and assays and methods for detecting tuberculosis infection in a sample.