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1. (WO2017156429) METHODS OF TREATING NEURODEGENERATIVE DISEASES

Pub. No.:    WO/2017/156429    International Application No.:    PCT/US2017/021858
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Sat Mar 11 00:59:59 CET 2017
IPC: A61K 38/16
A61K 31/497
Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventors: PEREIRA DA COSTA, Maria do Carmo
PAULSON, Henry, L.
Title: METHODS OF TREATING NEURODEGENERATIVE DISEASES
Abstract:
Methods of using the antipsychotic drug aripiprazole in treating a neurodegenerative disease such as Machado-Joseph disease/Spinocerebellar ataxia type 3 (MJD/SCA3) are disclosed. The methods comprise administering aripiprazole in an amount effect to decrease protein aggregates in the central nervous system and intracellular forms of pathogenic proteins such as mutant ataxin-3.