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1. (WO2017156427) ENGINEERED SCAFFOLDS FOR VASCULARIZED TISSUE REPAIR

Pub. No.:    WO/2017/156427    International Application No.:    PCT/US2017/021855
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Sat Mar 11 00:59:59 CET 2017
IPC: C08F 116/06
C08L 29/04
C09J 129/04
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventors: WANG, Aijun
LAM, Kit
Title: ENGINEERED SCAFFOLDS FOR VASCULARIZED TISSUE REPAIR
Abstract:
The present invention provides scaffolds that include a polymer and a cyclic peptide ligand. The peptide ligand increases the attachment of endothelial cells and/or progenitor cells to the scaffold. The present invention also provides engineered tissues that include the provided scaffolds. The present invention also provides coatings that include a coating polymer and a cyclic peptide ligand. The present invention also provides methods of improving endothelialization and vascularization of endothelial cells and/or progenitor cells for tissue regeneration in a subject and of repairing bone defects in a subject, by implanting a provided scaffold.