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1. (WO2017156424) MALASSEZIN AND ANALOGS THEREOF AS SKIN BRIGHTENING AGENTS

Pub. No.:    WO/2017/156424    International Application No.:    PCT/US2017/021843
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Sat Mar 11 00:59:59 CET 2017
IPC: C07D 487/04
C07D 209/12
A61K 8/49
Applicants: EINZIGER, Michael
SIMPSON, Ann Marie
Inventors: EINZIGER, Michael
SIMPSON, Ann Marie
Title: MALASSEZIN AND ANALOGS THEREOF AS SKIN BRIGHTENING AGENTS
Abstract:
The present invention relates to compounds, compositions, and methods for brightening skin. The compounds, compositions, and methods of the present invention generally involve compounds produced by a Malassezia yeast, and chemical analogs thereof. In addition to skin brightening applications, the compounds, compositions, and methods of the present invention may be used to modulate melanocyte activity, induce melanocyte apoptosis, agonize an arylhydrocarbon receptor (AhR), improve hyperpigmentation caused by a hyperpigmentation disorder, and modulate melanin production, melanosome biogenesis, and melanosome transfer.