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1. (WO2017156423) BROADLY PROTECTIVE ANTIBODY COCKTAILS FOR TREATMENT OF FILOVIRUS HEMORRHAGIC FEVER
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Pub. No.: WO/2017/156423 International Application No.: PCT/US2017/021842
Publication Date: 14.09.2017 International Filing Date: 10.03.2017
IPC:
A61K 39/395 (2006.01) ,C07K 16/10 (2006.01) ,C07K 16/08 (2006.01) ,A61K 39/42 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08
against material from viruses
10
from RNA viruses
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08
against material from viruses
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
42
viral
Applicants:
INTEGRATED BIOTHERAPEUTICS, INC. [US/US]; 4 Research Court Suite 300 Rockville, Maryland 20850, US
MAPP BIOPHARMACEUTICAL, INC. [US/US]; 6160 Lusk Boulevard No. C105 San Diego, California 92121, US
Inventors:
AMAN, Mohammad Javad; US
HOLTSBERG, Frederick Wayne; US
ZEITLIN, Laurence Mitchell; US
BORNHOLDT, Zachary Asa; US
Agent:
HOLTZ, William A.; US
HAANES, Betsy; US
BLUM, Anthony F.; US
BRAUNEL, Matthew A.; US
COLVIN, Katherine E.; US
DAVIS, J. Wendy; US
GERLACH, Robert D.; US
HIMICH, Matthew J.; US
JINKINS, David B.; US
KERCHER, Kevin M.; US
MOUSSAVI, Sartouk H.; US
MUSCH, Jonathan G.; US
NEPPLE, Michael L.; US
NORMAN, Alan H.; US
PARKS, Michael A.; US
POLCYN, Thomas A.; US
RITCHEY, Steven M.; US
ROMANO, Charles P.; US
SCHWENT, Jason M.; US
SMITH, Clyde L.; US
VOLK, Benjamin L.; US
Priority Data:
62/307,11811.03.2016US
62/368,68829.07.2016US
Title (EN) BROADLY PROTECTIVE ANTIBODY COCKTAILS FOR TREATMENT OF FILOVIRUS HEMORRHAGIC FEVER
(FR) COCKTAILS D'ANTICORPS LARGEMENT PROTECTEURS POUR LE TRAITEMENT DE LA FIÈVRE HÉMORRAGIQUE À FILOVIRUS
Abstract:
(EN) This disclosure provides a method for preventing, treating, or managing a filovirus infection in a subject, where the method includes administering to a subject in need thereof an effective amount of at least two anti-filovirus glycoprotein antibodies or antigen-binding fragments thereof where at least one of the antibodies or fragments binds to its orthologous filovirus glycoprotein epitope on two or more filovirus species or strains.
(FR) Cette invention concerne un procédé de prévention, de traitement ou de prise en charge d'une infection par filovirus chez un sujet, le procédé consistant à administrer à un sujet en ayant besoin une quantité efficace d'au moins deux anticorps de glycoprotéine anti-filovirus ou de fragments de liaison à l'antigène de ceux-ci, au moins l'un des anticorps ou fragments se liant à son épitope de glycoprotéine de filovirus orthologue sur au moins deux espèces ou souches de filovirus.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)