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1. (WO2017156416) COMPOSITIONS AND METHODS FOR TREATING CHEMOTHERAPY RESISTANT CANCER

Pub. No.:    WO/2017/156416    International Application No.:    PCT/US2017/021830
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Sat Mar 11 00:59:59 CET 2017
IPC: C12Q 1/68
G01N 33/574
G06F 19/00
Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
Inventors: KAHN, Josephine
JAISWAL, Siddhartha
EBERT, Benjamin
Title: COMPOSITIONS AND METHODS FOR TREATING CHEMOTHERAPY RESISTANT CANCER
Abstract:
The present invention features methods for increasing sensitivity and/or reversing resistance to chemotherapy, methods for treating or preventing a cancer in a subject, methods for treating clonal hematopoiesis of indeterminate potential in a subject, and methods of identifying resistance or sensitivity to chemotherapy in a subject. In some embodiments, the methods contain the step of administering an agent that inhibits the expression or activity of a Protein phosphatase 1D (PPM1D) polypeptide or polynucleotide. The present invention also features compositions for increasing sensitivity and/or reversing resistance to chemotherapy.