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1. (WO2017156365) METHODS OF GENERATING ANTIGEN-SPECIFIC T CELLS FOR ADOPTIVE IMMUNOTHERAPY
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Pub. No.: WO/2017/156365 International Application No.: PCT/US2017/021730
Publication Date: 14.09.2017 International Filing Date: 10.03.2017
IPC:
C12N 5/0783 (2010.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
078
Cells from blood or from the immune system
0783
T cells; NK cells; Progenitors of T or NK cells
Applicants:
MEMORIAL SLOAN KETTERING CANCER CENTER [US/US]; 1275 York Avenue New York, NY 10065, US
Inventors:
KOEHNE, Quenther; US
Agent:
ANTLER, Adriane M.; US
FRIEBEL, Thomas, E.; US
GEORGE, Nikolaos, C.; US
INSOGNA, Anthony, M.; US
ROWAN, Thomas, G.; US
Priority Data:
62/307,24011.03.2016US
Title (EN) METHODS OF GENERATING ANTIGEN-SPECIFIC T CELLS FOR ADOPTIVE IMMUNOTHERAPY
(FR) PROCÉDÉS DE GÉNÉRATION DE LYMPHOCYTES T SPÉCIFIQUES À UN ANTIGÈNE POUR UNE IMMUNOTHÉRAPIE ADOPTIVE
Abstract:
(EN) Provided herein are methods of generating antigen-specific T cells for therapeutic administration to a human patient having or suspected of having a pathogen or cancer using a CD34 fraction of an apheresis collection from G-CSF mobilized donors. Also disclosed are methods of treating a human patient using antigen-specific T cells generated by such methods, and methods of assessing antigen-specific T cells for suitability for therapeutic administration to a human patient.
(FR) La présente invention concerne des procédés de génération de lymphocytes T spécifiques à un antigène pour une administration thérapeutique à un patient humain atteint ou soupçonné d'être atteint d'un pathogène ou d'un cancer à l'aide de la fraction CD34 d'une collection d'apharèse de donneurs de G-CSF mobilisés. L'invention concerne également des procédés de traitement d'un patient humain à l'aide de lymphocytes T spécifiques à un antigène générés par ces procédés et des procédés d'évaluation des lymphocytes T spécifiques à un antigène pour leur adéquation pour une administration thérapeutique à un patient humain.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)