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1. (WO2017156311) COMBINATION VECTORS AND METHODS FOR TREATING CANCER
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Pub. No.: WO/2017/156311 International Application No.: PCT/US2017/021639
Publication Date: 14.09.2017 International Filing Date: 09.03.2017
IPC:
C12N 15/11 (2006.01) ,C12N 15/113 (2010.01) ,C12N 15/86 (2006.01)
[IPC code unknown for C12N 15/11][IPC code unknown for C12N 15/113][IPC code unknown for C12N 15/86]
Applicants:
AMERICAN GENE TECHNOLOGIES INTERNATIONAL INC. [US/US]; 15010 Broschart Rd. #110 Rockville, MD 20850, US
Inventors:
LAHUSEN, Tyler; US
LIOU, Mei-Ling; US
XIAO, Lingzhi; US
LI, Haishan; US
PAUZA, Charles, David; US
Agent:
MULHOLLAND, William, F.; US
Priority Data:
62/305,94409.03.2016US
Title (EN) COMBINATION VECTORS AND METHODS FOR TREATING CANCER
(FR) VECTEURS DE COMBINAISON ET MÉTHODES DE TRAITEMENT DU CANCER
Abstract:
(EN) A composition for treating cancer is disclosed. The composition includes a lentiviral particle and an aminobisphosphonate drug. The lentiviral particle is capable of infecting a target cell, such as a cancer cell, and includes an envelope protein optimized for targeting such target cell and a viral vector. The viral vector includes a small RNA optimized to target an FDPS mRNA sequence. The aminobisphosphonate drug includes zoledronic acid.
(FR) La présente invention concerne un procédé de traitement du cancer. La composition comprend une particule lentivirale et un médicament aminobisphosphonate. La particule lentivirale est capable d'infecter une cellule cible, telle qu'une cellule cancéreuse, et comprend une protéine d'enveloppe optimisée pour cibler ladite cellule cible et un vecteur viral. Le vecteur viral comprend un petit ARN optimisé pour cibler une séquence d'ARNm de FDPS. Le médicament aminobisphosphonate comprend de l'acide zolédronique.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)