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1. (WO2017156291) METHODS AND SYSTEMS FOR ASSESSING INFERTILITY AND OVULATORY FUNCTION DISORDERS
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Pub. No.: WO/2017/156291 International Application No.: PCT/US2017/021605
Publication Date: 14.09.2017 International Filing Date: 09.03.2017
IPC:
C12Q 1/68 (2006.01) ,G01N 33/53 (2006.01) ,G01N 33/50 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Applicants:
CELMATIX INC. [US/US]; 14 Wall St, Suite 16D New York, NY 10005, US
Inventors:
BEIM, Piraye, Yurttas; US
PARFITT, David, Emlyn; US
HU-SELIGER, Tina; US
SANTISTEVAN, Anthony; US
Agent:
MEYERS, Thomas, C.; US
HYDE, Zachary, D.; US
MAGGIN, Benjamin, D.; US
LEONARDO, Mark, S.; US
HSIAO, Weber; US
Priority Data:
62/306,02709.03.2016US
Title (EN) METHODS AND SYSTEMS FOR ASSESSING INFERTILITY AND OVULATORY FUNCTION DISORDERS
(FR) PROCÉDÉS ET SYSTÈMES POUR ÉVALUER LA STÉRILITÉ ET LES TROUBLES DE LA FONCTION OVULATOIRE
Abstract:
(EN) The present invention relates to methods and systems for assessing risk of infertility and ovarian dysfunction and/or diminished ovarian reserve and/or for determining an appropriate course of treatment. In some embodiments, the invention provides methods for assessing likelihood of ovarian dysfunction, including identifying a plurality of genetic variants that are filtered into functional biological pathways. The frequency distribution of the variants in each functional pathway is then compared to frequency distributions obtained from reference sets corresponding to each pathway. Further embodiments of the invention comprise clustering subjects based on patterns in their genetic variants, and identifying phenotypic differences with respect to ovarian dysfunction between clusters of patients.
(FR) La présente invention concerne des procédés et des systèmes permettant d'évaluer un risque de stérilité et de dysfonctionnement ovarien et/ou une réserve ovarienne réduite et/ou de déterminer un traitement approprié. Dans certains modes de réalisation, l'invention concerne des procédés permettant d'évaluer la probabilité d'un dysfonctionnement ovarien, les procédés comprenant l'identification d'une pluralité de variants génétiques qui sont filtrés dans des voies biologiques fonctionnelles. La distribution de fréquence des variants dans chaque voie fonctionnelle est ensuite comparée à des distributions de fréquence obtenues à partir d'ensembles de référence correspondant à chaque voie. D'autres modes de réalisation de l'invention comprennent le regroupement de sujets sur la base des profils de leurs variants génétiques, et l'identification de différences phénotypiques par rapport à un dysfonctionnement ovarien entre des groupes de patients.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)