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1. (WO2017156272) RECOMBINANT HIV-1 ENVELOPE PROTEINS AND THEIR USE

Pub. No.:    WO/2017/156272    International Application No.:    PCT/US2017/021573
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Fri Mar 10 00:59:59 CET 2017
IPC: A61K 39/12
C07K 14/005
Applicants: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Inventors: LUSSO, Paolo
ZHANG, Peng
Title: RECOMBINANT HIV-1 ENVELOPE PROTEINS AND THEIR USE
Abstract:
Embodiments of HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. Nucleic acid molecules encoding the HIV-1 Env ectodomain trimers are also provided. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject, for example, to treat or prevent an HIV-1 infection in the subject.