Search International and National Patent Collections

1. (WO2017156270) CXCR-2 INHIBITORS FOR TREATING CRYSTAL ARTHROPATHY DISORDERS

Pub. No.:    WO/2017/156270    International Application No.:    PCT/US2017/021570
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Fri Mar 10 00:59:59 CET 2017
IPC: A61K 31/506
C07D 205/04
C07D 239/56
C07D 403/12
Applicants: ARDEA BIOSCIENCES, INC.
Inventors: NANAVATI, Payal
MINER, Jeffrey
Title: CXCR-2 INHIBITORS FOR TREATING CRYSTAL ARTHROPATHY DISORDERS
Abstract:
N-(2-((2,3-difluorobenzyl)thio)-6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)pyrimidin-4-yl)azetidine-1-sulfonamide (compound 3) and N-(6-(((2R,3S)-3,4-dihydroxy butan-2-yl)oxy)-2-((4-fluoro benzyl)thio)pyrimidin-4-yl)-3-methylazetidine-1-sulfonamide(compound 4) are known chemokine modulators and are therefore useful in the treatment of diseases/conditions in which modulation of chemokine receptor activity is beneficial. In particular, provided herein are compositions and methods for the treatment and prevention of gout.