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1. (WO2017156266) METHODS OF TREATING DEPRESSION USING OREXIN-2 RECEPTOR ANTAGONISTS
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Pub. No.: WO/2017/156266 International Application No.: PCT/US2017/021565
Publication Date: 14.09.2017 International Filing Date: 09.03.2017
IPC:
A61K 31/498 (2006.01) ,A61K 31/5377 (2006.01)
[IPC code unknown for A61K 31/498][IPC code unknown for A61K 31/5377]
Applicants:
JANSSEN PHARMACEUTICA NV [BE/BE]; Turnhoutseweg 30 B-2340 Beerse, BE
Inventors:
KENT, Justine, M.; US
DREVETS, Wayne, C.; US
DE BOER, Peter; BE
Agent:
FARSIOU, David, N.; US
PALOVICH, Tracy, U.; US
Priority Data:
62/306,48710.03.2016US
Title (EN) METHODS OF TREATING DEPRESSION USING OREXIN-2 RECEPTOR ANTAGONISTS
(FR) MÉTHODES DE TRAITEMENT DE LA DÉPRESSION À L'AIDE D'ANTAGONISTES DE RÉCEPTEURS DE L'OREXINE-2
Abstract:
(EN) The present disclosure is directed to, inter alia, methods of treating a subject suffering from or diagnosed with depression, comprising administering to a subject in need of such treatment an effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein R1 to R4 are described herein and wherein the compound is administered prior to sleep.
(FR) La présente invention concerne, entre autres, des méthodes de traitement d'un sujet souffrant d'une dépression ou chez qui une dépression a été diagnostiquée, comprenant l'administration à un sujet ayant besoin d'un tel traitement d'une quantité efficace d'un composé de formule (I), ou d'un sel pharmaceutiquement acceptable de celui-ci, dans laquelle les R1 à R4 sont décrits dans la description, et le composé étant administré avant le coucher.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)