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1. (WO2017156238) PROTEIN STABILITY-BASED SMALL MOLECULE BIOSENSORS AND METHODS

Pub. No.:    WO/2017/156238    International Application No.:    PCT/US2017/021526
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Fri Mar 10 00:59:59 CET 2017
IPC: G01N 33/566
G01N 33/74
Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventors: CHURCH, George M.
MANDELL, Daniel J.
FENG, Justin
Title: PROTEIN STABILITY-BASED SMALL MOLECULE BIOSENSORS AND METHODS
Abstract:
The disclosure provides a biosensor having a ligand binding domain (LBD) or its variant, wherein the stability of the LBD or its variant is conditioned on the presence of specific small molecule ligands, and wherein the LBD or its variant is fused to a reporter protein. The disclosure also provides a method of screening for small molecules that modulate protein stability.