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1. (WO2017156214) PHARMACEUTICAL COMPOSITIONS FOR COLON-SPECIFIC DELIVERY

Pub. No.:    WO/2017/156214    International Application No.:    PCT/US2017/021492
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Fri Mar 10 00:59:59 CET 2017
IPC: A61K 9/28
A61K 9/14
A61K 9/48
A61K 8/49
A61K 47/36
A61K 47/38
A61K 47/58
Applicants: GATEWAY PHARMACEUTICAL LLC
Inventors: LI, Lianli
Title: PHARMACEUTICAL COMPOSITIONS FOR COLON-SPECIFIC DELIVERY
Abstract:
Disclosed are pharmaceutical particulates which release a pharmaceutical compound into the colon following oral administration. A particulate comprises a core comprising a pharmaceutical compound, an inner coating surrounding the core, wherein the inner coating comprises a pharmaceutically acceptable polysaccharide that is susceptible to enzymatic digestion by one or more enzymes present colonic microflora, and an outer coating surrounding the inner coating, wherein the outer coating comprises a polymer which is stable at upper gastrointestinal pH but can dissolve at colon luminal pH in less than about 60 minutes. The core of a particulate can further comprise an excipient such as a diluent, a binder, a disintegrant, a lubricant, a glidant or a combination thereof. Particulates can comprise pharmaceutical compounds for treating colonic diseases such as C. difficile colitis, ulcerative colitis, and Crohn's disease.