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1. (WO2017156178) INDUCIBLE BINDING PROTEINS AND METHODS OF USE

Pub. No.:    WO/2017/156178    International Application No.:    PCT/US2017/021435
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Thu Mar 09 00:59:59 CET 2017
IPC: C07K 16/28
C07K 16/18
C07K 16/30
A61K 39/395
Applicants: MAVERICK THERAPEUTICS, INC.
Inventors: BAEUERLE, Patrick
DUBRIDGE, Robert, B.
WESCHE, Holger
EVNIN, Luke
GUENOT, Jeanmarie
PANCHAL, Anand
VINOGRADOVA, Maia
Title: INDUCIBLE BINDING PROTEINS AND METHODS OF USE
Abstract:
Provided herein are conditionally activated polypeptide constructs comprising a protease-activated domain binding to CD3, at least one half-life extension domain, and two or more domains binding to one or more target antigens. Also provided are pharmaceutical compositions thereof, as well as nucleic acids, recombinant expression vectors and host cells for making such polypeptide constructs. Also disclosed are methods of using the disclosed polypeptide constructs in the prevention, and/or treatment diseases, conditions and disorders.