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1. (WO2017156170) USE OF MODIFIED HIV-1 FOR GENERATING FULLY HUMAN ANTIBODIES
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Pub. No.: WO/2017/156170 International Application No.: PCT/US2017/021426
Publication Date: 14.09.2017 International Filing Date: 08.03.2017
IPC:
A61P 37/00 (2006.01) ,A61K 39/21 (2006.01) ,C12Q 1/70 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
21
Retroviridae, e.g. equine infectious anemia virus
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
70
involving virus or bacteriophage
Applicants:
UNIVERSITY OF MASSACHUSETTS [US/US]; One Beacon Street, 31st Floor Boston, Massachusetts 02108, US
Inventors:
LUBAN, Jeremy; US
Agent:
VELEMA, James H.; US
TRINQUE, Brian C.; US
ALTER, Scott; US
ANIS, Hissan; US
BARONE, Stephen B.; US
BARTON, Steven K.; US
CAUBLE, David F.; US
CHAPMAN, Gary B.; US
CHEN, Xiaoyue (Peter; US
COUGHLIN, Sean M.; US
CURTIS, Michael J.; US
DECONTI, Giulio A.; US
DELANEY, Marie; US
DIZEREGA, Philip; US
DZURELLA, Palmer; US
JEFFRIES, James H.; US
JOHNSON, Joseph; US
KNAPP, Jacquelyn D.; US
LAMBRECHTS, Robert J.; US
LINK, Douglas; US
MACK, Brian R.; US
POPLIN, Alan J.; US
QUINN, Anna; US
SENDEK, Timothy; US
SPELLBERG, Michael; US
STEELE, Alan; US
STERNSTEIN, Allan; US
STONE-HULSLANDER, Judith; US
SULLIVAN, Sally A.; US
TEOFILO, Javier; US
TREMBATH, Jon; US
VICKERY, Neal; US
VOCK, Curtis A.; US
WASHINGTON, Michele; US
WILKINS, Andrew T.; US
ZHOU, Wen (Lily); US
Priority Data:
62/305,89109.03.2016US
Title (EN) USE OF MODIFIED HIV-1 FOR GENERATING FULLY HUMAN ANTIBODIES
(FR) UTILISATION DE VIH-1 MODIFIÉ POUR LA GÉNÉRATION D’ANTICORPS COMPLÈTEMENT HUMAINS
Abstract:
(EN) The present invention provides highly efficient methods, and compositions related thereto, for generating high titer human antibodies or antibody fragments thereof in a mammalian subject. The methods comprise administering a virus or virus-like particle to a mammal comprising heterologous immune cells and isolating a population of immunoglobulin-producing cells from the mammal, thereby producing the antibodies or antibody fragments thereof.
(FR) La présente invention concerne des procédés hautement efficaces, et des compositions associées, pour la génération d’anticorps humains à titre élevé ou de leurs fragments d’anticorps chez un sujet mammifère. Le procédé consiste à administrer un virus ou une particule de type virus à un mammifère comprenant des cellules immunitaires hétérologues et à isoler une population de cellules productrices d’immunoglobuline provenant du mammifère, produisant ainsi les anticorps ou leurs fragments d’anticorps.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)