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1. (WO2017156164) 20-HETE RECEPTOR (GPR75) ANTAGONISTS AND METHODS OF USE

Pub. No.:    WO/2017/156164    International Application No.:    PCT/US2017/021419
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Thu Mar 09 00:59:59 CET 2017
IPC: A61K 31/197
A61K 31/231
C07C 275/20
C07C 229/30
C07D 303/42
Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
NEW YORK MEDICAL COLLEGE
Inventors: FALCK, John, R.
SCHWARTZMAN, Michael, L.
GARCIA, Victor
Title: 20-HETE RECEPTOR (GPR75) ANTAGONISTS AND METHODS OF USE
Abstract:
The present invention concerns compounds and their use to treat cardiovascular disease, renal disease, thrombic disease, stroke, metabolic syndrome, cell proliferation, and ischemic cardiovascular disorders. Compounds of the present invention display significant potency as antagonists of 20-hydroxyeicosatetraenoic acid (20-HETE), and function as anti-hypertensive, anti-inflammatory, or anti-growth agents.