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1. (WO2017156128) PEPTIDE MODULATORS OF SPECIFIC CALCINEURIN PROTEIN-PROTEIN INTERACTIONS

Pub. No.:    WO/2017/156128    International Application No.:    PCT/US2017/021363
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Thu Mar 09 00:59:59 CET 2017
IPC: A61K 38/03
C07K 14/47
Applicants: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Inventors: GROSS, Eric
HURT, Carl
MOCHLY-ROSEN, Daria
Title: PEPTIDE MODULATORS OF SPECIFIC CALCINEURIN PROTEIN-PROTEIN INTERACTIONS
Abstract:
Methods of modulating the interaction between calcineurin and a calcineurin-binding protein partner are provided. Aspects of the methods include contacting a cell with a peptidic agent that modulates the interaction between calcineurin and a TRPV channel. Also provided are pharmaceutical compositions that comprise a peptidic agent that selectively modulates the interaction between calcineurin and a calcineurin-binding protein partner. Also provided are methods of treating a condition in a subject by selectively modulating the interaction between calcineurin and a calcineurin-binding TRPV channel. Also provided are screening methods to identify candidate agents that modulate calcineurin protein-protein interactions.